DHEA and Aging

DHEA levels are directly related to the probability of dying in humans.

In a 12-year study of over 240 men aged 50-79 years old, researchers found that DHEA levels were inversely correlated with mortality for heart disease and all other known causes. This finding suggests that DHEA levels can become a standard diagnostic tool in the prediction of disease, mortality and lifespan.

Dr. Ronald Klatz in his book Stopping The Clock mentioned that “studies have shown that DHEA prolongs life expectancy up to an amazing 50% in laboratory animals. If animal results hold true in humans, supplemental DHEA may prevent disease, reduce mortality, and extend life span.

DHEA is a “precursor” hormone – that is, it is the mother hormone that the body can convert into over 50 essential hormones, including testosterone, estrogen, progesterone and cortisone to name a few.

According to Dr. William Regelson of the Medical College of Virginia, DHEA is “one of the best biochemical bio-markers for chronological age.” In fact, some people's levels of DHEA decline 95% during their lifetime – the largest age related decline of an important biochemical yet documented, and an indication of Dhea's beneficial effect on the aging process.

In 1995 at a meeting entitled DHEA AND AGING in Washington DC, John Nestler in his talk hypothesized that the age-related drop in DHEA and DHEA-S, may be due in part to the normal age-related rise in circulating insulin levels. Thus increasing insulin, may indeed be one of the main reasons that DHEA declines with age, and an inverse relationship may indeed be possible; as DHEA levels are enhanced then insulin may drop.

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